Submit any drug-condition-population hypothesis
Engine runs cohort cuts, PSM, era stratification, and signs the result.
Tier-classified output
ROBUST_PUBLISHABLE → ROBUST → CANDIDATE → HYPOTHESIS_GENERATING → CONFOUNDED_INVERTED → PANDEMIC_ARTIFACT.
Cryptographic provenance per finding
Ed25519 signature, public verify URL, no authentication required to validate.
Private dataset uploads
Encrypted at rest, scoped to your session, never crosses to the credentialed cohort path.
Methodology transparency
40 covariates, 1:1 nearest-neighbor matching, caliper 0.2·SD, era stratification all surfaced per finding.
Cross-dataset replication
MIMIC-IV 3.1 (94,458 ICU stays per PhysioNet release; Caliper filters to a credentialed adult subset) and eICU-CRD 2.0 (200,859 unit stays across 208 hospitals). Patient-level data never leaves the credentialed path.
Validate your hypotheses with the propensity-score-matching rigor that FDA RWE frameworks expect
Targets: real-world evidence teams, pharmacoepidemiology groups, signal-detection scientists, clinical-pharmacology directors, biotech R&D teams. 50 hypothesis validations per day, 500 per month, up to 5 team accounts under one organization. Every result cryptographically signed.
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